2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140303
    DBCO-PEG9-DBCO 2353409-50-2
    DBCO-PEG9-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG9-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG9-DBCO
  • HY-141050
    N-PEG3-N'-(propargyl-PEG4)-Cy5 2107273-06-1
    N-PEG3-N'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-PEG3-N'-(propargyl-PEG4)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-PEG3-N'-(propargyl-PEG4)-Cy5
  • HY-140917
    Dde Biotin-PEG4-Picolyl azide 2055048-42-3
    Dde Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Dde Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Dde Biotin-PEG4-Picolyl azide
  • HY-140804
    Azide-PEG16-alcohol
    Azide-PEG16-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG16-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG16-alcohol
  • HY-W096139
    Br-PEG3-ethyl acetate 308085-31-6
    Br-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Br-PEG3-ethyl acetate
  • HY-138741
    Azido-PEG12-propargyl 2264091-72-5
    Azido-PEG12-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG12-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Azido-PEG12-propargyl
  • HY-140429
    t-Boc-Aminooxy-PEG7-amine 2226611-29-4
    t-Boc-Aminooxy-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Aminooxy-PEG7-amine
  • HY-138744
    DBCO-PEG13-NHS ester
    DBCO-PEG13-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG13-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG13-NHS ester
  • HY-23212
    2-Amino-1,3-bis(carboxylethoxy)propane 1020112-73-5
    2-Amino-13-bis(carboxylethoxy)propane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    2-Amino-1,3-bis(carboxylethoxy)propane
  • HY-140660
    Azide-PEG-alcohol (MW 2000)
    Azide-PEG-alcohol (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG-alcohol (MW 2000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG-alcohol (MW 2000)
  • HY-140672
    m-PEG-acrylate (MW 20000)
    m-PEG-acrylate (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-acrylate (MW 20000)
  • HY-144076
    t-Boc-amido-PEG10-acid
    t-Boc-amido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-amido-PEG10-acid
  • HY-113828
    Biotin-PEG2-C4-alkyne 1011268-28-2
    Biotin-PEG2-C4-alkyne is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Biotin-PEG2-C4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Biotin-PEG2-C4-alkyne
  • HY-140556
    N-Boc-N-bis(PEG4-azide) 2055041-25-1
    N-Boc-N-bis(PEG4-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Boc-N-bis(PEG4-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-Boc-N-bis(PEG4-azide)
  • HY-144080
    Bromo-PEG5-CH2COOtBu
    Bromo-PEG5-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG5-CH2COOtBu
  • HY-140605
    m-PEG3-Sulfone-PEG3-acid 1919045-04-7
    m-PEG3-Sulfone-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-Sulfone-PEG3-acid
  • HY-117186
    Bis-propargyl-PEG6 400775-35-1
    Bis-propargyl-PEG6 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG6 can be used to synthesize the polymer linked multimers of guanosine-3', 5'-cyclic monophosphates. Bis-propargyl-PEG6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG6
  • HY-140913
    Biotin-PEG23-azide
    Biotin-PEG23-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG23-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG23-azide
  • HY-133353
    Mal-PEG6-mal 2752168-26-4
    Mal-PEG6-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG6-mal
  • HY-134683
    Ms-PEG3-NHS ester
    Ms-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ms-PEG3-NHS ester
PROTAC Linkers Isoform Comparison

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